“A full course of Daigo eliminates harmful gut bacteria, promotes the growth of beneficial microflora, and activates intestinal immune cells.”
— Dr. Hiromi Shinya, Professor of Surgery, Albert Einstein College of Medicine
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World’s first & only. Daigo is a next-gen Japanese gut support formula — not a probiotic, but a metabiotic.
It delivers ready-made metabolites from 16 strains of beneficial lactobacilli, produced through a time-tested fermentation process.
Feel lighter, more regular, and more energized — every day. Daigo supports digestion, skin, immunity, and energy by nourishing your own microbiome with fermented metabolites.
Especially effective for:
✅ Bloating, irregular digestion, and constipation
✅ Gut imbalance from antibiotics or stress
✅ Low energy and slow metabolism
✅ Skin issues linked to gut health
✅ Long-term microbiome support and prevention
🇯🇵 Made in Japan. 100% natural.
Suitable for adults, kids, pregnant women, and diabetics. Backed by over 110+ years of microbiome research and a Nobel-winning discovery.
For Adults:
Daily dose – starting from 10 ml (2 sachets).
Mix with clean water. Take 2 to 5 sachets per day.
For Children:
For Infants:
The metabolites in Daigo create the ideal environment for the growth of your own native gut bacteria.
Metabiotics support the body through multiple mechanisms:
Study by Kyushu University School of Medicine and BOOCS Clinic (Fukuoka, Japan):"Impact of Daigo on gastrointestinal disorders."
Study by Okita Medical Clinic (Japan):"Use of Daigo in the management of seasonal allergic rhinitis (pollinosis),"
Study by the Spanish company Life Length, dated September 6, 2019:"Assessment of cell proliferation rate and telomere length in primary adult human fibroblast cultures treated with Daigo," and "Evaluation of Daigo’s effects on telomerase activity in primary human fibroblasts using the MTT assay and Q-TRAP test system under laboratory conditions."
Kyushu University, Japan: 62% effectiveness in combating colon polyps
Albert Einstein College of Medicine, USA: Significant improvement in gut health among oncology patients
Niigata University, Japan: Proven to improve Th1/Th2 immune balance and stimulate immune cell activity
Kid-friendly formula
Safe for pregnancy
Safe for diabetics
Senior-safe care
Allergen-Free
No Artificial Additives
100% Organic
Vegan Friendly
Lactosa Free
Gluten Free
Non-GMO
Restores a healthy gut microbiome balance
Improves intestinal motility and regularity
Normalizes bowel movements (both constipation and diarrhea)
Reduces bloating and gas by up to 84%
Relieves discomfort and supports natural detoxification
Helps with dysbiosis and Irritable Bowel Syndrome (IBS)
Activates intestinal immune cells (Peyer’s patches)
Promotes a healthier Th1/Th2 immune balance
Doubles immune cell activity
Reduces the frequency of colds by 62%
Enhances the body’s defense against viruses and allergens
Reduces H. pylori colonization by 58–77%
Helps soothe stomach lining inflammation
Prevents gastritis and peptic ulcers
Works without side effects
Improves skin health (reduces inflammation, acne, psoriasis):
75% noticed improved skin elasticity
92% reported better moisture retention
75% noticed improved skin elasticity
Boosts nutrient absorption
Freshens breath and supports oral health
Promotes kidney health and daily energy levels
Unlike probiotics or antibiotics, Daigo uses a next-gen approach to restore balance in your gut — without adding live bacteria or disrupting your system.
Powered by Microbiome Science. Daigo is a metabiotic — its key ingredients are bioactive secretions naturally produced by beneficial lactobacilli during fermentation.
These secretions, also called “territorial substances,” act like a protective zone that supports good bacteria and keeps harmful ones in check.
When your gut microbiome is in balance, your body runs smoother, your digestion improves, and your immune defenses stay strong — just the way nature intended.
93%
of Daigo users report little to no bloating by week 1 (1 box)
82%
of Daigo users noticed improved digestion and metabolism in 1-1,5 month (3 box)
87%
of Daigo users reported an improvement in gas in as little as 1 week (1 box)
Albert Einstein College of Medicine, USA
Significant improvement in gut health among oncology patients
Kyushu University, Japan
62% effectiveness in combating colon polyps
Niigata University, Japan
Proven to improve Th1/Th2 immune balance and stimulate immune cell activity
“A full course of Daigo eliminates harmful gut bacteria, promotes the growth of beneficial microflora, and activates intestinal immune cells.”
— Dr. Hiromi Shinya, Professor of Surgery, Albert Einstein College of Medicine
Supports gut flora balance and reduces intestinal inflammation.
Helps soothe digestive discomfort and promotes regularity.
Boosts immunity and improves lactose digestion.
Helps reduce symptoms of bloating, gas, and food sensitivities.
Enhances nutrient absorption and maintains vaginal and gut pH balance.
Known for combating Candida and supporting skin clarity.
Protects the intestinal lining and reduces inflammation.
Aids in healing leaky gut and supports metabolism and immune response.
Rich in antioxidants and supports detoxification.
Helps fight oxidative stress and improves liver function.
Supports oral, gut, and skin microbiome balance.
Reduces bad breath, strengthens immunity, and may relieve eczema.
Improves gut barrier integrity and mood-related neurotransmitter levels.
Shown to increase GABA production, reducing stress and anxiety.
Strong immune support and protection against harmful bacteria like Helicobacter pylori.*
Reduces risk of infections and supports gut-brain axis for better mood and clarity.
Bioavailability
✅ Maximum — no activation needed
⚠️ Depends on bacterial survival
⚠️ Indirect effect
Onset of Action
✅ Immediate effect from day one
⏳ Requires regular intake
⏳ Needs time to build
Risk of Bacterial Conflict
✅ None — no live bacteria
⚠️ May cause imbalance in sensitive gut
☑️ None
Temperature Stability
✅ Shelf-stable — no refrigeration needed
⚠️ Often needs cold storage
☑️ Stable
Use in IBS, SIBO, Dysbiosis
✅ Safe and effective in all cases
❌ Often worsens symptoms
⚠️ Mild, limited effect
Active Metabolites Present
✅ Yes — includes SCFAs, enzymes, peptides, etc.
⚠️ Only if bacteria survive and colonize
❌ None
Anti-inflammatory Action
✅ Strong — reduces gut & skin inflammation
⚠️ Depends on strain
❌ Not applicable
Immune Modulation
✅ Regulates without overstimulation
⚠️ Unpredictable immune effects
❌ Not effective
Brain–Gut–Skin Axis Benefits
✅ Supports mood, digestion & skin from within
⚠️ Possible but indirect
❌ No direct impact
Compatible with Medications
✅ Safe with antibiotics and other treatments
❌ Often killed by antibiotics
☑️ Compatible
Technological Advancement
✅ Next-gen (postbiotic) technology
⚠️ Conventional live cultures
⚠️ Basic fiber-based compounds
WHO & Scientific Recognition
✅ Aligned with latest microbiome research
⚠️ Becoming outdated in clinical use
⚠️ Supplemental role only
Universal Effectiveness
✅ Works regardless of your microbiome profile
⚠️ Depends on existing bacteria
⚠️ Works only if right bacteria are present
Hypoallergenic & Family-Safe
✅ Safe for children, pregnancy, elderly, sensitive individuals
⚠️ May cause side effects or intolerance
☑️ Well tolerated
Digestive Comfort
✅ No fermentation, no bloating, no gas
⚠️ May cause bloating/gas
⚠️ Often causes gas
ABOUT DAIGO AND HOW IT WORKS
COMPOSITION AND SCIENTIFIC BASIS
HOW TO TAKE IT
HEALTH IMPACT AND PREVENTION
SAFETY AND DURATION OF USE
ABOUT DAIGO AND HOW IT WORKS
What is Daigo?
Daigo is an organic dietary supplement from Japan, belongs to the class of metabiotics. It contains 2 valuable components: valuable secretion from 16 species of beneficial lactobacilli and their cellular material. Daigo creates an ideal environment for the growth of your native beneficial intestinal bacteria, while blocking pathogenic microflora, helping to restore a healthy balance of intestinal microflora and proper functioning of the GI tract. The cellular material of bacteria included in Daigo helps to restore and strengthen the immune system.
What is the difference between Daigo and Daigo Lux?
Daigo Lux contains 1.5 times more active ingredients than Daigo. Also during the production process, Daigo Lux undergoes an additional degree of fermentation, which significantly increases the digestibility of the product. Daigo Lux works faster than Daigo, but at a lower dosage. One bottle is enough for a full course.
Where is Daigo manufactured?
Daigo is manufactured in Japan. The manufacturing plant is located 90 kilometers southwest of Tokyo, in the town of Fujinomiya at the foot of Mount Fuji. The area is a national nature reserve, providing ideal environmental conditions for organic production. Production complies with the high international GMP standard.
What is a GMP standard?
GMP (Good Manufacturing Practices) is a manufacturing control certificate that is a guarantee of high quality and ensures that quality standards are met in the production and testing of drugs or active ingredients (APIs). Some of the main factors for certification are the following checks: whether the specified ingredients are contained, whether the ingredients are present in the specified amounts, and whether the product contains no ingredients that do not belong in it.
What are metabiotics?
Metabiotics (from the Greek words “methos” - after and “bios” - life, i.e. “after life”). This is a kind of environment favorable for the life and growth of beneficial bacteria. They are special active substances (secretions, enzymes, nucleic acids) formed during the vital activity of bacteria and the very bodies of these bacteria (cellular material). Metabiotics do not contain any living bacteria. Metabiotics provide a favorable environment for the growth and development of your native beneficial bacteria while blocking the reproduction of pathogenic ones. Metabiotics are currently the most effective means of restoring a healthy balance of intestinal microflora and the body's defenses. Metabiotics can vary in quality and, accordingly, in price.
How does Daigo boost immunity?
Daigo contributes to this important task by awakening dormant immune cells in the intestine. The bacterial bodies (cellular material) in Daigo stimulate the dormant immune cells to work, thereby increasing the number of active immune cells and restoring the body's defenses.
How does the metabiotic Daigo affect the microbial population in the gut?
The valuable secretory secretions from 16 species of beneficial lactobacilli in Daigo create an ideal environment for the growth and multiplication of beneficial intestinal bacteria in humans themselves. At the same time, the reproduction of pathogenic microflora is suppressed and its number is brought to a safe minimum. Thus, the correct healthy balance of intestinal microflora is formed, in which there are much more beneficial bacteria than pathogenic ones.
COMPOSITION AND SCIENTIFIC BASIS
What microorganisms are contained in Daigo metabiotic?
Daigo does not contain any microorganisms. Daigo contains only valuable secretory secretions (enzymes) from 16 species of beneficial lactobacilli, which help to create an ideal environment for the growth of your native beneficial intestinal microflora while suppressing pathogenic microflora. The second valuable component of Daigo is the cellular material of 16 species of beneficial lactobacilli, which help to restore the body's defenses.
Does Daigo contain additional ingredients?
Daigo contains, in addition to the valuable secretion of 16 species of beneficial lactobacilli and their cellular material, citric and lactic acids and water. Daigo dietary supplement does not contain: GMO, gluten, saccharides/sweeteners.
Has the effectiveness and safety of the product been proven?
Yes, the effectiveness and safety of the product has been proven. The product has undergone numerous tests and studies in Japan and Europe. You can read about them on our website in the “Research” section.
HOW TO TAKE IT
How often should I take the metabiotic Daigo and Daigo Lux?
Daigo or Daigo Lux can be taken either as a course (for 3 or 6 months) or as a long-term, permanent treatment. The minimum recommended course is 3 months. For maximum effective results, the daily dosage and regimen are selected individually. Daigo or Daigo Lux can be taken before, after or during meals.
Can Daigo be taken with other medicines?
Daigo is not a medicinal product, but a functional food, so it is fully compatible with other supplements and medicines. If you are undergoing medical treatment and have a serious medical condition, we recommend that you consult with your physician for inclusion of Daigo in the complex therapy and prescription of the correct dosage.
Can Daigo Metabiotic be taken together with probiotics?
Yes, you can. Daigo is fully compatible with other supplements and medications. Just why take a metabiotic with a probiotic? Modern metabiotics, as a means of restoring a healthy balance of intestinal microflora, are much more effective than probiotics.
Can Daigo Metabiotic be used for weight loss?
It is clinically proven that obese people lack the right microorganisms in their gut to support a healthy metabolism and normal weight. By helping to restore a healthy balance of intestinal microflora, Daigo participates in the correction of all types of metabolism and promotes weight normalization. In the course of a full course you will notice how the qualitative composition of your microflora changes, beneficial bacteria begin to predominate: your eating habits will change towards proper nutrition, you will want more greens, vegetables, fruits, much less sweets, flour and fast food.
Is a special diet required when taking Daigo metabiotic?
No, Daigo does not require special conditions for taking and following a diet.
Does Daigo help after taking antibiotics?
Of course, taking Daigo after taking antibiotics has several important benefits:
Helps minimize the disastrous effects of the antibiotic on beneficial microflora, preventing dysbacteriosis;
Blocks the reproduction of pathogenic microflora;
Taking Daigo after a course of antibiotics helps restore a healthy balance of native intestinal microflora, proper functioning of the GI tract and improve health.
If you are prescribed a course of antibiotics, Daigo can be taken together with antibiotics and continue to take after the end of the course of antibiotics for 3 months.
HEALTH IMPACT AND PREVENTION
Should you take Daigo metabiotic for the prevention of intestinal diseases?
Of course! A course intake of metabiotic Daigo is recommended for the prevention of various diseases of the GI organs, allergies and others. It is recommended to take at least 2 preventive course doses during the year, especially in spring and fall.
Can the metabiotic Daigo alleviate digestive problems?
Yes, it can. That's exactly what it was created to do. For over 100 years, its unique formula has been proving its effectiveness. A course intake of Daigo helps to settle various digestive problems through restoring the proper balance of the native intestinal microflora and the body's defenses. Daigo also has a positive effect on the treatment of many diseases: dysbacteriosis, flatulence, irritable bowel syndrome, stool problems, heartburn, ulcers, gastritis, SIBR, etc.
Can the metabiotic Daigo help with irritable bowel syndrome?
Yes! Daigo, by restoring a healthy balance of your intestinal microflora, helps to resolve various problems related to the gastrointestinal tract and has a positive effect on the treatment of many diseases: irritable bowel syndrome, dysbacteriosis, flatulence, stool problems, heartburn, ulcers, gastritis, SIBR, etc.
SAFETY AND DURATION OF USE
Are Daigo and Daigo Lux metabiotics safe for pregnant and breastfeeding women?
Daigo Metabiotics and Daigo Lux are completely safe organic products belonging to the functional food category. They have been successfully studied with pregnant women in Japan. In Russia, such studies have not been conducted, so so far the contraindications to taking them include: pregnancy and breastfeeding.
Is there a possibility of side effects or allergic reaction to metabiotics Daigo and Daigo Lux?
No side effects have been detected when taking Daigo and Daigo Lux. On the contrary, Daigo Metabiotics and Daigo Lux are modern effective allergy remedies. Since the products do not contain any type of saccharides - this is an additional guarantee for the absence of side effects and allergic reactions.
How long do I need to take Daigo metabiotic to see results?
Daigo is a broad-spectrum organic product that works at the cellular level, gradually restoring immunity and a healthy balance of your native intestinal microflora. Daigo takes time to create visible results, and to stabilize the positive healing trend of your body. This is why doctors recommend course or long-term use of Daigo. As a rule, positive changes begin to appear at the end of the first month of use and achieve significant results after a full course (3, 6 or 12 months).
"I want lactobacilli to make everyone healthy."
Kakutaro Masagaki
More than 100 years of history, currently shaped by the fourth generation of Japanese researchers and businesspeople, impress.
Today, we operates powerful production and research facilities making it possible to achieve its main goal of making healthy as many people as possible.
The main tool for achieving company's goals is the fermentation extract of lactic acid bacteria Daigo®.
Daigo is produced at our dedicated facility at the foot of Mount Fuji, located in a pristine and eco-friendly region of Japan.
In addition to owning the factory, the company also cultivates its own soybeans on private fields specifically for Daigo production.
Organic, pesticide-free soybeans grown in eco-friendly conditions
16 strains of Lactobacillus cultured together in harmony
A 365-day fermentation process ensures maximum concentration of beneficial compounds
1,000× higher than what's found in cow’s milk
Only the secreted bioactive compounds and cell materials are collected, with no live bacteria
Rigorous quality control at every stage of production
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SINCE 1914 YEAR
Our Story
Our story began with the discovery of the Theory of Longevity by the founder of longevity science and modern medicine, Immunology and Gerontology Pioneer, Nobel Prize Laureate in Physiology and Medicine in 1908, Élie Metchnikoff. And was developed by four generations of inspired
Japanese scientists who dedicated themselves to making a breakthrough in longevity, health, well-being and preventive solutions to deliver superior products to the modern world over the years.
100% organic products have no analogues due to it’s composition contains the most valuable secretions for human health from 16 types of beneficial lactobacilli and their cellular material.
Metabiotic Daigo is a mixture of peptides - bioregulators extracted from bacterial cells of 16 strains of physiological lactic acid bacteria that colonize healthy human intestines.
It is not a probiotic. It is not a prebiotic.
Metabiotic Daigo helps to improve the balance of TH1 helper cells to TH2 helper cells, making the body strong and resistant to infections and viruses
•Metabiotic Daigo slows down the rate of telomere* contraction by more than 2 times, thereby prolonging the life of the cell and the entire body
*telomeres are repeating sequences of DNA found at the tips of human chromosomes, and responsible for Longevity
Daigo's philosophy and values relate to a healthy lifestyle, longevity, beauty from the inside.